Bioinformatics

Modern analysis and high-throughput methods help researchers in life sciences to better understand biological systems. This results in large amounts of data that can only be processed, analyzed and interpreted in a time-saving manner with suitable software applications and computer-based procedures.

The quality and significance of the results depend on how these applications are selected, configured and linked to analysis pipelines. Analysis pipelines comprise several steps that are combined to form a process chain and must therefore be precisely coordinated in order to guarantee a smooth process. This requires a team of experienced experts. In addition to the conversion of file formats and data structures between the modules of the pipeline, the correct selection and configuration of parameters is a challenge and is important for the subsequent evaluation and quality assurance of the results. It is therefore crucial that the people responsible for data analysis have a high degree of biological expertise, technological know-how, and experience in the development of solution strategies for complex problems - characteristics that the bioinformatics specialists at solveno bring with them.

solveno's scientists and software engineers cover all major areas of bioinformatics - from DNA sequence and gene expression analysis to the creation of biological networks in systems biology and image analysis. Additional networking with experts from other disciplines ensures that you as a customer receive exactly the know-how you need. The versatility and many years of experience of our employees make it possible to quickly grasp new questions and implement their solutions efficiently. Careful coordination of all processes in advance increases the quality of the results and reduces the effort required to establish a successful solution for the analysis of your data. solveno accelerates your research analyses and optimizes your data processing, especially with these services:

  • Customized consulting in all questions of bioinformatics
  • Support in the development of application-specific software
  • Selection and configuration of commercially available bioinformatics tools
  • Design of analysis pipelines
  • Analysis and meaningful processing of data

DNA sequence analysis
- fast and secure

One of our areas of expertise is DNA sequence analysis. Next Generation Sequencing (NGS) data (e.g. genome sequences) are typed and patterns identified using analytical methods.

We can detect pathogenic germs (e.g. a type of bacteria) by sequencing a smear test sample. We then find out against which antibiotics the identified bacterial species is resistant. Doctors can use these clinically relevant statements to develop a strategy to cope with hospital germs quickly and reliably.

Gene expression analysis
- efficient and reliable

During the production of new drugs, their efficacy and possible side effects must be investigated. To this end, we analyze how the genetic information is converted, for example, in a cell, a cell group or a specific tissue type (gene expression). This allows us to draw conclusions about how the system reacts to certain external influences and treatments.

solveno supports you in the preparation of your gene expression data, the static evaluation and validation of the results. Due to our many years of experience and know-how in this specialist area, we increase the efficiency of your data evaluation.

Biological networks in system biology
- understanding complexity

Biological processes within an organism are controlled by both genes and by a large number of cellular components such as proteins or metabolites. Systems biology aims to describe a biological system - wholly or partially - using models and thus gain a better and more detailed understanding of the processes of a living cell. This enables more reliable predictions to be made, for example when it comes to the effects of an active substance on a clinical picture.

These models include biological networks (e.g. co-expression networks, protein-protein interaction networks). They are used in systems biology to present and analyze the relationships, interactions, and interdependencies between the various components.

Our bioinformatics specialists help you to model, establish and statistically analyze such networks. This allows you to better exploit the potential of the data and gain a better understanding of the interrelationships between different components.

Image analysis
- meaningful and objective

The analysis of image data in microscopy is an essential aspect of the description of quantitative characteristics of cells, cell groups and tissues. This allows statements to be made on the shape (e.g. size and morphology), function and dynamics of biological systems.

We support you in extracting and analyzing all information relevant to your research from a large number of image files. We offer solutions for automated pre-processing of raw data (e.g. two- and three-dimensional image data sets), robust identification (segmentation) and tracking of objects (e.g. cells), and statistical analysis of extracted characteristics. For your microscopy laboratory, we put together suitable automated, fast and flexible pipelines to obtain the maximum amount of information from your image data.

With our help, you accelerate your research project and your scientists can concentrate on the interpretation of the results and planning of further experiments.

 

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